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The objective of this study was to investigate whether increased plasma levels of glycosaminoglycans (GAGs) are associated with hepatocyte lysis in experimental acute liver disease. After administration of dimethylnitrosamine in two different doses, GAG concentrations were measured in plasma and in circulating cell-associated GAGs (cCAG) of mononuclear cells, platelets and erythrocytes. In addition, the plasma volume, the total protein and albumin concentrations were determined and histological changes in the liver were quant be359ba680
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